LongLifeList — longevity, fact-checked. Go to home page
Join free

Planning and self-assessment

Supplement Stack Checker

Enter what you take. The tool sorts it by evidence grade and flags the interactions we have evidence for — including the ones with prescription medicines.

Formula lll-supplement-stack-1.0.04 sources6 stated limitationsClinical estimate

This page has no named medical reviewer on file. The equation it implements is published and cited below, but the page itself has not been signed off by a member of the review board, and we do not present it as if it had been.

Enter your numbers

44 questions. Questions that only apply to some people appear once your earlier answers decide that they do.

Supplement Stack Checker inputs

Prescription medicine, not a supplement.

Prescription medicine, not a supplement.

Nothing you type is stored unless you are signed in and ask us to save it.

How this is calculated

Formula version lll-supplement-stack-1.0.0

The member ticks the supplements and medicines they take. Each supplement is looked up in a catalogue that records its active-ingredient groups and an indicative monthly retail cost. Any interaction row whose two members are both present fires, sorted by severity; any active-ingredient group claimed by more than one item is reported as a duplicated active. Evidence grades are injected by the caller and default to UNGRADED, and grade F produces an explicit stop warning. Costs are summed, with items lacking a cost figure reported separately so the total is never silently understated. Grades, the interaction table and costs are all injectable parameters of `checkSupplementStack`.

What it cannot do

  • No doses are collected, and nearly every interaction here is dose-dependent.
  • The default interaction table is a starter set of about eighteen rows, not a pharmacological database. Absence of a flag is not evidence of safety.
  • Three rows are marked LLL editorial rather than sourced to a fact sheet.
  • Evidence grades are placeholders unless the application injects real ones.
  • Costs are LLL indicative retail estimates in USD and are not cited prices.
  • Timing, formulation and bioavailability differences between products are not modelled.

Sources

  1. NIH Office of Dietary Supplements, Health Professional fact sheets (Vitamin K, Vitamin E, Omega-3 Fatty Acids, Zinc, Calcium, Iron, Magnesium)View source (opens in a new tab)
  2. National Center for Complementary and Integrative Health: St John's WortView source (opens in a new tab)
  3. National Center for Complementary and Integrative Health: MelatoninView source (opens in a new tab)
  4. LLL evidence grades are injected by the application from the LLL evidence library; this calculator declares the shape only

The formula version is pinned so that a result you saved or shared can be reproduced. When we change a coefficient, the version changes and old results stay attributed to the version that produced them.

Questions people ask

Is a missing interaction a safe interaction?
No. Absence from this list means we have no evidence of an interaction, which is not the same as evidence of no interaction. Supplement interactions are poorly studied and under-reported. A pharmacist reviewing everything you actually take is better than any tool.
Why is something I have read a lot about graded low?
Because attention and evidence are measured separately here, and the gap between them is the most useful thing on many of our pages. A high-hype, low-evidence supplement is the most common item in a stack.